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In this case, three main treatment options exist: amputation, radiation therapy and combination of surgery with radiation therapy. Amputation is an aggressive treatment option with the best chance of controlling the tumor but it will also affect the dog's function. Radiation therapy alone has had varying degrees of success. Combining radiation with surgery offers an attractive alternative to limb amputation, in which the surgery removes as much of the mass as possible and the radiation beam kills any remaining cancer cells left behind. Alternative treatments may include surgical removal followed by chemotherapy or chemotherapy alone but the benefit of these treatments is not established. Regardless of the procedure chosen, the dogs should be evaluated on regular basis to monitor for local tumor recurrence and possible metastasis. High grade (highly aggressive) mct easily accessible for complete surgical removal For easily accessible mcts, complete surgical removal is the treatment of choice, followed up by histologic evaluation to ensure completeness of surgery. The surgery will typically remove not only the tumor itself but also surrounding normal tissue to ensure that no cancer cells are left behind. If the histologic evaluation confirms that no cancer cells were present in the healthy tissues, then chemotherapy is used to try to kill any circulating tumor cells that are likely to be present due to the aggressive behavior of high grade tumors.

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What are the treatment options for dogs with mast cell tumors? Treatment zout strategies will largely depend on the tumor's grade (level of aggressiveness) and how advanced the disease. In addition to treating the tumor itself, some cases may also require treatment with anti-histamine medication and/or drugs to relieve gastrointestinal ulceration associated with mcts. Low or intermediate grade (mildly aggressive) mct easily accessible for complete surgical removal For easily accessible mcts, surgical removal is the treatment choice, followed up by histologic evaluation to ensure completeness of surgery. The surgery will typically remove not only the tumor itself but also normal tissue surrounding the tumor to ensure that no cancer cells are left behind.

If the histologic evaluation confirms that no cancer cells were present in the healthy tissues, then the dogs should either come for routine check ups on regular basis to monitor possible tumor recurrence/metastasis or the pet owners can agree to chemotherapy. In this setting, the goal of chemotherapy would be to prevent or minimize the risk of metastasis (cancer spread) and/or local tumor recurrence. Because of the lack of adequate studies, veterinary oncologists seem to disagree on the potential benefit of chemotherapy in this particular scenario. If the histologic evaluation confirms the presence of cancer cells in the healthy tissues, then additional treatments are necessary to prevent the tumor from growing back and spreading to distant sites. These will typically include either additional surgery that will remove larger area around the tumor and/or radiation therapy and/or chemotherapy. Recently, the arsenal of anti-cancer therapies for canine mast cell tumors included targeted therapies as summarized in more detail in the next section. Low or intermediate grade (mildy aggressive) mct not easily accessible for complete surgical removal For tumors that are not easily accessible for complete surgical removal such as distal extremities (eg paws it is usually recommended that an incisional biopsy is done prior to deciding.

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Untreated pain decreases the pet's quality of life, and prolongs recovery from the illness, treatment or injury. It is, therefore, essential that veterinary teams that are taking care of pets with cancer should also play a vital role in educating pet owners about recognizing and managing pain in their pets. The best way to manage cancer pain in pets is to prevent it, a term referred to as preemptive pain management. This strategy anticipates pain ahead of time and administers pain medication before the pet actually experiences pain, thus ensuring the pet's maximum comfort. To learn more about which tumors are likely to cause a lot of pain, how to recognize pain in pets with cancer and what cancer pain management options are available for your pet, please visit the cancer pain Management section.

Is nutritional support important for pets with cancer? Cancer cachexia (a term referring to progressive severe weight loss) is frequently observed in pets with cancer. Pets with cancer lose weight partly because of lack of appetite and partly because of cancer-induced altered metabolism. Some of the causes for decreased appetite are related to the cancer itself (for example, tumors may physically interfere with food chewing, swallowing, and digestion process) and some may be related to the side effects of cancer treatment (for example, some chemotherapy drugs cause nausea. Proper nutrition while undergoing cancer treatment is essential to maintain your pet's strength, improve survival times, quality of life and maximize response to therapy. Adequate nutritional support was shown to decrease the duration of hospitalization, reduce post- surgery complications and enhance the healing process. Additionally, pets with cancer need to be fed diets specifically designed to provide maximum benefit and nutritional support for the patient. To learn more, please visit the cancer Nutrition section.

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Additional diagnostic steps will vary depending on the tumor's location, size and initial findings. If the tumor is located at a site easily accessible for surgical removal, and no obvious negative prognostic factors are present, the tumor is usually surgically removed and the sample sent to pathology lab for evaluation. If the tumor develops at a site where complete surgical removal is not possible and/or if additional negative prognostic factors are present, further diagnostic tests are done prior to initiating treatment. The veterinarian will typically examine sale the regional lymph nodes to check for metastasis (spread of cancer cells do blood test to check for overall health of the pet, buffy coat smear to check for circulating mast cell tumor cells throughout the body, abdominal ultrasound. Advanced imaging such as ct (computed tomography) can be a very useful diagnostic tool that can evaluate the extent of the disease in more detail and can aid the oncologist in planning an appropriate treatment strategy. Does cancer cause pain in pets? Pain is common in pets with cancer, with some tumors causing more pain than others. In addition to pain caused by the actual tumors, pets will also experience pain associated with cancer treatments such as surgery, radiation therapy or chemotherapy.

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The clinical symptoms of dogs with mcts may be complicated due to the release of chemicals by the tumor cells, which can cause gastrointestinal ulceration (open sores). In slokdarmcarcinoom this case, the dogs may experience vomiting, anorexia, dark feces and abdominal pain. How is the diagnosis made? The world health Organization has developed a clinical staging system for canine mast cell tumors, reflecting the natural progression of the disease. This system is by no means absolute and serves only as a guide. Mast cell tumors are initially diagnosed by fine-needle aspriation (FNA) cytology. While fna is useful, it does not provide any information about the tumor's grade (level of aggressiveness and biopsy is therefore recommended.

Labrador retrievers tend to have more aggressive tumors and golden retrievers tend to have multiple tumors. What are the symptoms of mast cell tumors in dogs? Skin mcts are usually detected by owners as raised lumps on the skin which can have a wide range of appearance, from a wart-like nodule (mass) to a soft subcutaneous lump to an ulcerated skin mass. Mcts that peeling are located underneath the skin appear as soft nodules and can be misdiagnosed as lipoma. Most tumors are solitary (single mass) but 11-14 of dogs can have multiple tumors. The appearance of these tumors depends on how differentiated the tumor cells are (how much their appearance still resembles mast cells). Tumors that are composed of cells that resemble mast cells under the microscope are usually slow growing and not ulcerated, although the hair may be lost in the area. Tumors that are composed of cells that no longer resemble mast cells are typically rapidly growing and ulcerated. Surrounding tissues may become inflamed and edematous (swollen due to fluid accumulation with small nodules forming nearby.

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How common are mast cell tumors in dogs? Skin mcts are the most common type of mast cell tumors, accounting for zwarte 16-21 of all skin tumors in the dog. The average age at diagnosis is 8 years but puppies as young as 4 months have been reported. There is some evidence that certain breeds may be at higher risk of developing skin mast cell tumors, including boxers, bulldog breeds, bullmastiffs, boston terriers, Staffordshire, rhodesian ridgbacks, pugs, labradors retrievers, golden retrievers, weimaraners, and beagles. Although mast cells are also present in the lung and gastrointestinal tract, the development of tumors in these sites is not as common as for the skin. Skin mcts are most commonly found on the trunk (50-60) and the limbs (25). MCTs that are located underneath the skin appear as soft nodules and can be misdiagnosed as lipoma. Although boxers, bulldogs and pugs are at increased risk of developing skin mast cell tumors, they tend to have less aggressive tumors.

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